Wang Shao-xia
2012
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Quality indicators
Journal
Journal of Tianjin University of Traditional Chinese Medicine
Abstract
[Objective] This study examined whether 1.8-Dihydroxy-3-carboxy-anthraquinone,a metabolite from Salvia miltiorrhiza,may exert an anti-inflammatory effect in microglia.[Methods] We examined the effect of 1.8-Dihydroxy-3-carboxy-anthraquinone on cell viability and the production of nitric oxide(NO) induced by LPS treatment in rat primary cultured microglia.[Results] 1.8-Dihydroxy-3-carboxy-anthraquinone could significantly inhibit the production of NO by LPS treatment in rat primary cultured microglia.[Conclusion] 1.8-Dihydroxy-3-carboxy-anthraquinone can suppress microglial activation and this may be a mechanism underlying the neuroprotective activity of it.