A. Palamar, I. Yaremii, V. Chornous
Feb 1, 2021
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Quality indicators
Journal
Pharmaceutical Chemistry Journal
Abstract
The effects of [(1-phenyl-5-formyl-1H-imidazol-4-yl)thio]acetic acid on oxidant-antioxidant homeostasis in rats with tetrachloromethane poisoning were studied. This compound was found to normalize most parameters of the oxidant-antioxidant balance in the liver and kidneys of animals with toxic hepatitis. These results point to the ability of compounds of this type to suppress free-radical lipid oxidation and oxidative protein modification processes and to activate the antioxidant protection system in animal tissues.