S. Z. Li, J. Cheng, H. Z. Ma
Mar 1, 1982
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Quality indicators
Journal
Zhongguo yao li xue bao = Acta pharmacologica Sinica
Abstract
This paper presents the effects of 2,2-dimethylthiazolidine-HCI (DMTD), a radioprotective agent, on cancer radiosensitivity. The weights of tumor masses of sarcoma 180, measured 1d after the completion of irradiation, showed no difference between DMTD-protected and nonprotected groups. The regression of S180 was observed in 2/7 DMTD-protected mice 2 wk after the completion of exposure. Meanwhile, the average weights (g) of tumor masses of S180 were 4.6±(SD) 2.8 and 8.4±2.4 (P 0.05) in DMTD-protected and nonprotected mice, respectively, 6.5±2.8 and 7.4±3.5 (P>0.05) in DMTD-treated and controlled mice, respectively. DMTD showed no significant effect on the weight of spleen and the average survival time in reticular-cell leukemia of mice (L615). These data suggest that DMTD neither decreased the radiosensitivity of S180, EAC and L616, nor enhanced the growth of these transplantable mouse tumors. On the contrary, DMTD exerted some inhibitory effects on tumor cell growth of S180 and EAC, and rendered the tumor cells more sensitive to irradiation.