T. Imahayashi, M. Shimada, H. S. Ozaki
2005
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Journal
Journal of Neural Transmission
Abstract
In the present work, the effects of 3-acetylpyridine (3-AP) on the adrenal medulla were investigated for biochemical and morphological changes. Adrenaline- and noradrenaline-storing cells treated with 3-AP one day previously had lost almost all their granules. A large number of lipoid droplets appeared in the cytoplasm. At the same time, the concentrations of adrenaline and noradrenaline cells were significantly decreased below control values (P< 0.01). However, these significant changes were ameliorated 19 days after 3-AP treatment. Morphologically and biochemically, the adrenaline- and noradrenaline-storing cells had recovered completely at 35 days.