R. Morin, W. Burkart, M. V. Srikantaiah
Apr 1, 1979
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Biochemical Pharmacology
Abstract
Abstract Administration of 4-aminopyrazolopyrimidine (4-APP) to rabbits resulted in a 63 per cent decrease in plasma cholesterol concentration and a 9-fold increase in platelet hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase activity. In individual rabbits, the degree of stimulation of HMG-CoA reductase activity was strongly correlated with the extent of reduction of plasma cholesterol (r 0.987). Reduction of plasma and platelet cholesterol concentrations by 4-APP treatment was associated with reduced sensitivity of platelets to aggregation by adenosine diphosphate and collagen.