M. Shimizu, Tatsuhiko Koizumi, H. Inoue
Apr 21, 1994
Citations
0
Influential Citations
9
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract A 2′- O _methyloligo(pyrimidine)nucleotide containing a 5-methyl-2′- O -methyluridine ( I ) forms a more stable triple-helix with double-stranded DNA than the 5-unmodified parent probe, whereas 5-methyl-2′- O -methylcytidine ( II ) destabilizes the triplex. It is also shown that at low salt concentrations, the triplexes with 2′- O -methyl RNAs are more stable than the corresponding DNA-triplex.