Sleem F. Hmuda, Nebojsa Banjac, N. Trišović
2013
Citations
1
Influential Citations
4
Citations
Journal
Journal of The Serbian Chemical Society
Abstract
To obtain insight into the interactions of potential anticonvulsant drugs with their surrounding, two series of 5-methyl-5-aryl- and 5-ethyl-5- -arylhydantoins were synthesized and their absorption spectra were recorded in the region from 200 to 400 nm in a set of selected solvents. The effects of sol- vent dipolarity/polarizability and solvent-solute hydrogen bonding interactions on the absorption maxima shifts were analyzed by means of the linear solvation energy relationship (LSER) concept of Kamlet and Taft. The ratio of the con- tributions of specific and non-specific solvent-solute interactions were corre- lated with the corresponding absorption, distribution, metabolism, and excre- tion (ADME) properties of the studied compounds. The correlation equations were combined with different physicochemical parameters to generate new equations, which demonstrate the reasonable relationships between the sol- vent-solute interactions and the structure-activity parameters.