J. Rall, O. Pearson, M. Lipsett
Oct 1, 1956
Citations
0
Influential Citations
25
Citations
Journal
The Journal of clinical endocrinology and metabolism
Abstract
Triiodothyroacetic acid (3:5-diiodo-4-(3′-iodo-4′-hydroxyphenoxy)-phenyl acetic acid—hereinafter called triac) has been reported to cause, within thirty minutes, an increase in oxygen consumption in rat kidney slices (1). This effect was largely gone within four hours. In rats, triac and tetraiodothyroacetic acid (tetrac) have been tested for their antigoitrogenic properties and their effect on oxygen consumption. In general, both compounds are effective and have about one-tenth the potency of their respective parent compounds (2). It has been further shown that triac can induce changes in the feathers of birds, similar to those induced by thyroid hormone (3). In human subjects, triac has been reported to cause remission in the clinical features of myxedema and a depression in the serum cholesterol level, without change in basal oxygen consumption (4). In another study on a single case of myxedema a rise in basal metabolic rate (BMR) was observed after the administration of triac (5). It has been suggeste...