C. Blanco, Antonio Rojas, Dieudonné Nimubona
Mar 1, 2007
Citations
0
Influential Citations
26
Citations
Journal
Trends in Food Science and Technology
Abstract
Isohumulones exert bacteriostatic effects on most gram-positive bacteria. Hop compounds can cross cytoplasmic membranes in undissociated form, being dissociated internally. Transport pathway across cell membranes requires a reasonably hydrophobic solute of moderate size. Hydrophobicities of solutes can readily be determined by measuring partition coefficients, P. Therefore, in order to evaluate the antimicrobial activity of isohumulones and structurally similar molecules, a free energy correlation has been used which allows estimation of log P values. Moreover, the maximum molecular diameter of these molecules has been calculated by using an AM1 semiempirical calculation. A comparative analysis of the antimicrobial potential of the hop derived molecules which might be present in beer is then established.