Yang Lirong
2013
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Journal
Chinese Journal of Bioprocess Engineering
Abstract
Based on the kinetics study of enzymatic resolution,the structure of acyl donors was found to be an important factor for the kinetics resolution(KR)of secondary alcohol.With the commercially available Canadida rugosa lipase(CRL) as catalyst,the esters generated from a long carbon chain acid and chlorophenol were found to be efficient acyl donors and successfully applied for the kinetics resolution of secondary alcohols.In the KR of 1-phenylethanol,the e.e.p value increased when the longer carbon chain acid in the acyl donor was used.When the number of acyl carbon atoms was over five,the e.e.pvalue of 1-phenylethanol was nearly 100% at 50% conversion.The conclusion is also applicable to the KR of other secondary alcohols.The high selective factor could be achieved with 4-chlorophenyl valerate as the acyl donor.