R. L. H. HEIMANS, M. Rand, M. Fennessy
Nov 1, 1972
Citations
1
Influential Citations
40
Citations
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Journal
Journal of Pharmacy and Pharmacology
Abstract
Amantadine, in vitro, produced dose‐dependent blockade of dopamine uptake into a synaptosome‐rich particulate fraction of an homogenate of the basal ganglia of rats. A concentration of 3·6 times 10−6M was required to inhibit uptake by 50%. Diethazine was less potent in blocking dopamine uptake, the equiactive concentration being 8·0 times 10−6M. Amantadine and (+)‐amphetamine in concentrations in excess of 10−5M caused the release of small quantities of added dopamine from the particulate fraction.