N. Tanphaichitr, A. Agulnick, J. A. Hill
Jun 1, 1989
Citations
0
Influential Citations
11
Citations
Quality indicators
Journal
Contraception
Abstract
Aqueous-soluble gossypol Schiff's bases, SP562: bis-8,8'-[(N-(2-(dimethylamino)ethyl]-iminomethylene]- [1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2- binaphthalene dihydrochloride; SP563: bis-8,8'-[(N-(2-(diethylamino)ethyl]-iminomethylene]-1,1',6,6',7,7 '- hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'-binaphthalene++ + dihydrochloride; and SP564: bis-8,8'-[(N-(2-(diethylamino)propyl]-iminomethylene]- 1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'- binaphthalene dihydrochloride, were investigated for their effects on human sperm motility. SP564, which has the longest alkyl substituent of the Schiff's base, appeared to exert the greatest inhibitory effects on human sperm motility. These inhibitory effects were even greater than those caused by (+/-)gossypol acetic acid at the same concentration.