H. Garnett, R. Kemp, U. Gröschel‐Stewart
Feb 1, 1976
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Influential Citations
9
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Journal
Archives of biochemistry and biophysics
Abstract
Abstract The effect of mersalyl and of antibodies, directed against smooth-muscle myosin and skeletal muscle myosin, on the (Ca2+ + Mg2+)-activated adenosine triphosphatase (Ca,Mg)ATPase) system of mouse liver plasma membranes has been studied. Antismooth-muscle myosin inhibited by 38.6% at optimum substrate concentration the (Ca,Mg)ATPase with a Km of 0.88 × 10−3 m . Mersalyl (0.5 m m ) also inhibited this enzyme, the percentage inhibition being 44.6% at optimal substrate concentration. These results suggest the presence of a smooth-muscle myosin-like protein in the plasma membrane of mouse liver cells which has an associated (Ca,Mg)ATPase activity.