Wang Jian-wei
2010
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Journal
Journal of Jilin University
Abstract
Objective To study the effects of benserazide on extracellular dopamine level in the striatum of 6-hydroxydopamine-lesioned Parkinson's disease rat models.Methods The rat models of nigrostriatal denervation of Parkinson's disease were set up by using 6-hydroxydopamine(6-OHDA),and the control rats were treated with isotonic Na chloride.Then the extracellular dopamine(DA)level in the striatum of sham-lesioned rats treated with benserazide alone and in the striatum of 6-OHDA-lesioned rats treated with benserazide in combination with L-DOPA were detected by using in vivo microdialysis technique.Results In sham-lesioned rats,the extracellular DA level was significantly decreased by 50 mg·kg-1benserazide(P0.01).In 6-OHDA-lesioned rats,the extracellular DA level showed a marked increase by the combined use of benserazide and L-DOPA,but the time to reach the peak level was significantly prolonged on a dose-dependent manner(P0.05).Conclusion Benserazide can reduce the central AADC activity in the striatum of rats with nigrostriatal denervation,resulting in changes in metabolism of exogenous L-DOPA.And higher dose of benserazide might be a useful agent to prevent adverse effects of long-term L-DOPA therapy.