A. Stiehl, R. Raedsch, P. Czygan
Dec 1, 1980
Citations
2
Influential Citations
62
Citations
Quality indicators
Journal
Gastroenterology
Abstract
Abstract Chenodeoxycholic acid (cheno) and ursodeoxycholic acid (urso) dissolve cholesterol gallstones in humans. In the present study conjugation of biliary bile acids with glycine and taurine and their effects on biliary cholesterol saturation were investigated during treatment with cheno, urso, and cheno-urso. Ten patients were included in this study, and every patient served as his own control. Each of the treatment periods lasted for 3 mo. During treatment with cheno or urso, daily doses of 11.9–15.6 mg/kg were administered, while during treatment with chenourso each bile acid was administered at one-half the dose. In the control period biliary bile acids consisted of 31.8 ± 2.8% glycocheno, 10.9 ± 1.2% taurocheno, 1.0 ± 0.1% glycourso, and 0.3 ± 0.1% taurourso. During the three treatment periods dihydroxy bile acids in bile and glycine conjugation of these dihydroxy bile acids increased significantly (P