S. Panteleev, I. Sivachenko, O. Lyubashina
Aug 13, 2018
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Influential Citations
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Quality indicators
Journal
Neurogastroenterology & Motility
Abstract
Buspirone, a partial agonist of the 5‐HT1a receptor (5‐HT1aR), owing to potential antinociceptive properties may be useful in treatment of abdominal pain in IBS patients. The pain‐related effects of buspirone are mediated via the 5‐HT1aRs, specifically located within the ventrolateral medulla (VLM). The most animal studies of the 5‐HT1aR involvement in pain control have been carried out with somatic behavioral tests. The 5‐HT1aR contribution in visceral pain transmission within the VLM is unclear. The objective of our study was to evaluate the 5‐HT1aR contribution in abdominal pain transmission within the VLM.