T. Nitoda, T. Isobe, I. Kubo
Jul 1, 2008
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Phytotherapy Research
Abstract
Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16‐F10 melanoma cell line with an IC50 of 30 µm (9.5 µg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity. Copyright © 2008 John Wiley & Sons, Ltd.