M. El-Yousef, D. Manier
2004
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
Psychopharmacologia
Abstract
A randomly assigned control-experimental grouping with a crossover design, using subjects as their own controls, was utilized to study the effects of conjugated estrogens on plasma butaperazine (Repoise) levels in post-menopausal female subjects. Significantly higher plasma butaperazine levels were measured following both a single loading dose and with maintenance doses of oral butaperazine in subjects when they were taking conjugated estrogens as compared to when they were not taking conjugated estrogens. The underlying mechanisms for these findings and their clinical implications are discussed briefly.