J. Kuo, I. K. Dill, C. E. Holmlund
Apr 1, 1969
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Influential Citations
4
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Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract Deoxyfrenolicin, at an optimal concentration of about 15 to 20 μg ml , stimulated to a greater extent than did insulin the oxidation of glucose and fructose, presumably via the pentose cycle, by isolated adipose cells. Stimulation of glucose uptake and lipogenesis from glucose and fructose were lower than by insulin, however. At a higher concentration (60 μg ml ) of deoxyfrenolicin, the stimulatory effects were reduced or abolished. Deoxyfrenolicin, at a suboptimal concentration (10.5 μg ml ), stimulated still further the maximally stimulated lipogenesis from glucose and fructose in response to insulin or several “insulin-like” proteases. It is suggested that deoxyfrenolicin stimulated sugar utilization in isolated adipose cells, at least in part, through a mechanism different from the actions of insulin or proteases.