L. Xin
1997
Citations
0
Influential Citations
1
Citations
Quality indicators
Journal
Chinese Pharmacological Bulletin
Abstract
AIM:To study the effects of dihydroetorphine hydrochloride(DHE) on intestinal smooth muscles. Methods: To evaluate the differences in the effects of DHE and morphine on the intestinal smooth muscles of mice, rats and guinea pigs. Results:The effects of DHE on intestinal smooth muscles derived from mice, rats and guinea pigs were studied in vivo and in vitro . In vivo experiments, DHE 36 ̄60 μg·kg -1 and morphine 5 ̄20 mg·kg -1 sc could dose dependently relax the mouse intestinal smooth muscles; the median effective doses of DHE and morphine for slowing the mouse intestinal peritalsis were 3 23 μg·kg -1 and 2 79 mg·kg -1 sc respectively. In the isolated intestine preparations derived from mice, rats and guinea pigs,the intestinal smooth muscles were contracted by DHE at the concentrations of 10 ̄100, 0 1 ̄10 0 and 10 ̄100 μmol·L -1 as well as by morphine at the concentrations of 0 1 ̄10,0 002 ̄2 0 and 0 1 ̄10 0 μmol·L -1 respectively. The excitatory effects on intestinal smooth muscles were induced by DHE at the concentrations much higher than its pharmacological effective doses for inducing analgesia. Conclusion: DHE produces the relaxation but morphine produces the contraction of intestinal smooth muscles.