S. Meacock, E. Kitchen
Sep 1, 1979
Citations
1
Influential Citations
71
Citations
Quality indicators
Journal
Journal of Pharmacy and Pharmacology
Abstract
Possible modes of action of the anti‐inflammatory drug, benoxaprofen, have been explored. The drug caused inhibition of leucocyte migration, principally of mononuclear cells into the pleural cavity of rats undergoing carrageenan‐induced pleurisy. Evidence was obtained from in vitro leucocyte migration and chemotaxis models that the drug acted directly on the mononuclear cells rather than by inhibition of chemotactic factors.