G. Carpent, L. Desclin
Feb 1, 1969
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Journal
Endocrinology
Abstract
The mode of action of ergocornine was investigated by means of 2 different experimental procedures. A first group of animals was composed of hypophysectomized female rats bearing a pituitary under the kidney capsule, and daily injected with high dosages (15 μg) of estradiol. Whereas under these conditions the diestrus was maintained and the vagina had a gravid aspect, a single injection of ergocornine methanesulfonate (1 mg) restored vaginal cornification within a few days; it persisted as long as estradiol was injected. This suggests that ergocornine has been able to inhibit the elaboiation of pituitary prolactin, even suppressing the influence of estrogen on this process. In the second experimental group, ergocornine was given to pregnant rats. When it was administered on the 5th day at small dosages (0.18–0.3 mg), it did not interfere with implantation, which more particularly was neither delayed nor asynchronous. Dosages from 0.35 to 1.0 mg, although they did not always inhibit implantation, were very...