A. Merola, R. Dill, A. Arnold
Feb 1, 1968
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0
Influential Citations
26
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Journal
Archives of biochemistry and biophysics
Abstract
Studies with tissues from rats medicated orally with estrone or the estrogen, 17-(3-hydroxy-1-propmyl)-3-methoxyestra-1, 1,5(10)-17β-ol 17α-hydrocinnamate, have shown that cholesterol biosynthesis was inhibited at the decarboxylation of mevalonic acid in liver homogenates. In slices of livers from these rats inhibition also occurred at the cyclization of squalene. In contradistinction to the in vitro findings, evidence for inhibition of cholesterol synthesis could not be elicited in vivo. Labeling of the sterol pools prior to estrogen administration showed that a redistribution of cholesterol from blood to liver occurred so that the hypocholesteremia seen could best be described as due to a shift in the serum: liver cholesterol ratio.