C. Alvey, E. Randinitis, G. Rausch
Oct 1, 1999
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Drugs
Abstract
Clinafloxacin is an extremely potentmember of the quinolone class of synthetic antimicrobial agents. Compared with other available quinolones, clinafloxacin usually requires lower drug concentrations for bacterial inhibition and is active against a broader spectrum of organisms. It is effective against many multiple drug-resistant organisms and is active against many known quinolone-resistant strains. Clinafloxacin is being studied primarily in hospitalised adults for the treatment of serious and potentially life-threatening infections, including nosocomial pneumonia, community-acquired pneumonia, febrile neutropenia, complicated intra-abdominal infections, complicated skin and soft tissue infections, endocarditis, and acute gynaecological infections. Food and antacid are known to have varying effects on the pharmacokinetic profiles of other quinolone antibiotics. The purpose of these studies was to determine the effects of food and antacid on the pharmacokinetic profile of clinafloxacin and to recommend timing of food and antacid ingestion relative to clinafloxacin administration.