Hong‐Tai Chang, C. Jan, Wei-Zhe Liang
Feb 1, 2018
Citations
0
Influential Citations
11
Citations
Quality indicators
Journal
Journal of Functional Foods
Abstract
Abstract Oxidative stress has been implicated in the development of many diseases including cancer. Curculigoside, a phenolic glycoside, has been reported to protect various models against damage induced by oxidative stress. However, the protective effect of curculigoside on oxidative stress in normal human breast cells remains unclear. This study evaluated whether curculigoside protected MCF 10A human breast epithelial cells from H 2 O 2 -induced cytotoxicity and explored its underlying mechanisms. The H 2 O 2 -induced oxidative stress of cell models was demonstrated by decreased percentages of cell viability, increased levels of ROS, reduced activities in antioxidant enzymes, and inhibition of the expressions of antioxidant proteins. More importantly, pre-treatment with curculigoside significantly inhibited the H 2 O 2 -induced apoptosis in this cell model. Together, curculigoside significantly prevented the cytotoxic effects of H 2 O 2 , suggesting that it protected the cells against H 2 O 2 -induced oxidative damage. Our findings provide new insight into the cytoprotective effects of curculigoside and the possible mechanisms underlying these effects.