Chen Wen-fei
2013
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Quality indicators
Journal
Journal of Oral Science Research
Abstract
Objective: To study the effects of gossypol acetic acid(GAA)on proliferation and apoptosis of human tongue carcinoma cell line Tca8113.Methods: MTT assay and FCM were used to study the effect of GAA on the proliferation and apoptosis of human tongue carcinoma cell line Tca8113.Results: Experimental GAA group could be observed on proliferation inhibition of Tca8113 cells after being treated by GAA for 24h to 72h through MTT assay.Compared with the control group,the result of FCM assay indicated that GAA(30μmol/L GAA for 48h and 15μmol/L for 72h) induced a higher apoptosis rate of Tca8113 cells(P0.05).Conclusion: GAA has inhibitory effects on the proliferation and induces apoptosis of human tongue carcinoma cell line Tca8113.