Wu Dao-cheng
2010
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Journal
Journal of Modern Oncology
Abstract
Objective:To investigate the inhibitory effect of apogossypolone(ApoG2) on prostatic carcinoma,and explore its mechanism.Methods: To establish human prostatic carcinoma PC-3 cell line subcutaneous xenograft models and observe the inhibitory effect of ApoG2 on the tumor model.Immunohistochemistry was employed to observe the expression of bcl-2,PCNA,caspase-3 and-8 in tumor tissues.Results: ApoG2 can obviously inhibit the growth of subcutaneous prostatic carcinoma implant.The tumor volume decreased obviously.ApoG2 decreased the expression of PCNA and increased the expression of caspases-3,-8 in tumor tissues.Conclusion: ApoG2 has an inhibitory effect on prostatic carcinoma implants.