D. Liao, N. Lu, L. Lei
Jul 1, 1995
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
Zhongguo yao li xue bao = Acta pharmacologica Sinica
Abstract
AIM To study the effects of gypenosides (Gyp) on lymphocyte transformation and DNA polymerase II activity. METHODS Lymphocyte transformation response was induced by concanavalin A and lipopolysaccharides respectively. The activity of DNA polymerase II and DNA synthesis were assayed with TTP and [3H]TdR incorporation respectively in mixed lymphocyte culture test. RESULTS Gyp 2.5-20 mg L-1 enhanced splenic T- and B- cell transformation, increased the DNA synthesis and potentiated the activity of DNA polymerase II. However, Gyp > 40 mg L-1 showed contrary effects. CONCLUSION Gyp regulated lymphocyte transformation and DNA synthesis by regulating DNA polymerase II activity.