R. Swartz, F. Sidell
Jan 1, 1973
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Journal
Clinical Pharmacology & Therapeutics
Abstract
Pralidoxime chloride, used clinically to reactivate cholinesterase in organophosphate poisoning, is rapidly eliminated by the kidney. In these studies, heat and exercise stress significantly decreased the renal excretion of both pralidoxime and p‐aminohippurate (PAR) in man. Pharmacokinetic data suggest that the over‐all drug removal from plasma is also affected by changes in tissue distribution of these drugs: With stress conditions there is a marked increase in volumes of drug distribution. Furthermore, decreased total recovery of drugs in the urine under heat and exercise conditions implicate tissue metabolism as a factor of heretofore undetermined significance in the over‐all elimination of both pralidoxime and PAR.