Y. Kuroda
Feb 1, 1974
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
Cancer research
Abstract
Summary The effects of hexosamines and their acetyl derivatives on the aggregation of 4-dimethylaminoazobenzene-induced rat hepatoma cells, dRLa-74 and dRLh-84, which have a low and high tumor-producing activity, respectively, were examined in rotation-mediated cell culture. d-Glucosamine, d-galactosamine, and d-mannosamine had relatively little effect on aggregation of either strain of hepatoma cells at concentrations lower than 3 mm. At concentrations higher than 10 mm, some differential inhibitory effects on the aggregation of the two hepatoma cell lines were observed. d-Glucosamine and d-galactosamine were more effective against the aggregation of dRLh-84 cells than in that of dRLa-74 cells, and the reverse was the case with d-mannosamine. N -Acetyl-d-glucosamine, N -acetyl-d-galactosamine, and N -acetyl-d-mannosamine were relatively ineffective against the aggregation of dRLa-74 cells at all concentrations used. N -Acetyl-d-glucosamine had an inhibitory effect on the aggregation of dRLh-84 cells only at a concentration of 30 mm, while N -acetyl-d-galactosamine had a pronounced inhibitory effect at both 10 and 30 mm.