Zhang Xiao-l
2014
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Quality indicators
Journal
Clinical Focus
Abstract
Objective To evaluate the effects of ibandronate sodium on the treatment of maintenance hemodialysis(MHD)patients with osteoporosis or low bone mass.Methods Twenty MHD patients with osteoporosis or low bone mass were randomly divided into control group(n =10)and treatment group(n =10).Patients in the control group were treated with hemodialysis,three times per week.Patients in the treatment group received intravenous administration of ibandronate sodium immediately after hemodialysis with an initial dose of 1 mg and following dose of 2 mg every three months for 12 months.Results With 12 months' treatment of maintenance hemodialysis,patients in the control group got a decreased bone mineral density of the lumbar spine by 16.6%,which increased by 2.9%in the treatment group,showing significant difference between the two groups(P 0.01).The hip bone mineral densities in the two groups were both lower than that before treatment,especially in the treatment group(P 0.01).No significant differences of the serum calcium and phosphorus were found between the two groups(P 0.05),but serum phosphorus showed significant difference among the different time points(P 0.01).Conclusion Ibandronate sodium can effectively reduce the loss of bone mass and decrease the risk of bone fracture in MHD patients.