P. Lindgren, H. Nordenstam, G. Saltzman
Mar 1, 1966
Citations
0
Influential Citations
11
Citations
Journal
Acta Radiologica
Abstract
Iodipamide (Biligrafin, Cholografin) is one of the parenterally administered contrast media in daily use which may produce fairly severe side effects. The reactions observed clinically are too well known to need recapitulation in the present connection. Both clinical (SALTZMAN & SUNDSTROM) and experimental (LINDGREN & SALTZMAN, LINDGREN et colI.) studies have been carried out to ascertain the effect of the intravenous injection of iodipamide on the blood flow. The most striking reaction is a fall in the blood pressure immediately after the injection. As the kidneys have often proved to be highly sensitive to contrast media, especially to the di-iodized substances used earlier and to the acetrizoate preparations, it was thought that a study of the effect of iodipamide on the kidney might yield information of interest. The investigation was mainly concerned with the blood flow and histologic changes. The circulatory effects of iodipamide preparations somewhat resemble those evident after sodium acetrizoate injections (LINDGREN & SALTZMAN), both substances producing a marked fall in blood pressure.