Shiro Hiragata, Teruyuki Ogawa, P. Tyagi
Apr 1, 2006
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Journal
The Journal of Urology
Abstract
Hypothesis / aims of study Ajulemic acid (IP751) is a potent analog of tetrahydrocannabinol (THC)-11-oic acid, which is a major metabolite of THC, the principal psychotropic constituent of Cannabis. IP751 reportedly shows potent anti-inflammatory activity and is a powerful analgesic agent although the underlying mechanisms are still unknown. Thus, we hypothesized that IP751 is effective to suppress bladder overactivity and bladder pain responses in bladder hypersensitive disorders such as interstitial cystitis. Therefore, the present study was performed to investigate the effects of IP751 on bladder overactivity induced by acute and subacute bladder irritation in rats.