J. Forn, F. Valdecasas
Oct 1, 1971
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Journal
Biochemical pharmacology
Abstract
Abstract Sodium fluoride-induced adenyl cyclase activity of rat and rabbit cerebral cortex homogenates is inhibited by a wide range of concentrations of lithium. Lithium also inhibits NE-induced formation of cyclic AMP in cerebral cortex slices of rat, and histamine-induced formation of cyclic AMP in cerebral cortex slices of rabbit. The effects of lithium are already evident at a 2 mM concentration, and are specific for this ion. This concentration is easily achieved during the treatment of acute manic patients with lithium, suggesting that the psychosedative effects of lithium may be related to the inhibition of brain adenyl cyclase.