Liang Yue
2000
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0
Influential Citations
0
Citations
Quality indicators
Journal
Chinese Pharmacological Bulletin
Abstract
AIM To study the calcium antagonistic effects of Magnesium salicylate in central nervous system. MTEHODS Using calcium sensitive fluorescence indicator Fura-2 technique. RESULTS Resting [Ca 2+ ] i in brain cells under different extracellular calcium concentration(0,0 01,0 1,1 0,1 3 mmol·L -1 )were 41±5,59±6,84 7±2 5,104±7,(126±5)nmol·L -1 respectively( n =8~47).MgS 0 2 mmol·L -1 had no significant effects on resting [Ca 2+ ] i.At the same time, MgS (0 05~0 4 mmol·L -1 ) concentration dependently inhibited the [Ca 2+ ] i elevation induced by high extracellular potassium or L -glutamate in the presence of extracellular [Ca 2+ ] i 1 3 mmol·L -1 . The IC 50 values were 0 323 mmol·L -1 (95% CI 0 122~0 854 mmol·L -1 ) and 0 124 mmol·L -1 (95% CI 0 073~0 210 mmol·L -1 ) separately. CONCLUSION MgS possesses inhibitory effects on voltage-activated calcium channel and receptor-operated calcium chanel in CNS.