Edmont Laho, Xhejni Borshi
2018
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2018 UBT International Conference
Abstract
Drugs like metoclopramide are used in pediatric patients for the treatment of frequent vomiting or gastrointestinal disorders especially at the age of three. The most common use is Reglan solution, but its dose should be strictly observed because of low therapeutic index overdose is easily achieved, manifesting with extrapyramidal side effects. The purpose of the study is to detect the frequent side-effects of the extrapyramidal nervous system that are due to the oral overdose of Reglan in the pediatric population. Materials and methods. This study analyzed all the cases of Metoclopramide toxicity who took the Reglan solution in an outpatient setting and were then diagnosed and treated in the Pediatric Service in the Hospital of Elbasan during January 2014 to December 2016 period. These cases have been treated in the Pediatric Service in Elbasan. After having been diagnosed with signs of the nervous system from the overdose of Reglan solution they were surveyed in terms of dose taken, duration of use, age, etc. Results. The17 cases diagnosed in our service varied in clinical presentation from nuchal rigidity to whole body contractions and somnolence. Out of these, nine children were younger than 1 year old, 5 children 1-4 years old, and 3 children were aged 4-8 years. All the children younger than one received Reglan solution at high doses 3 times 1 coffee spoon (also fivefoldtenfold of the dose) while the therapeutic dose for Reglan solution is 0.1mg / kg in 3-4 doses. Conclusions. Considering this medication has a low therapeutic index, cautions to prescribe and administer the right dose are of the upmost importance. As a result, the general practitioner and the pharmacists should be instructed that children younger than 1 year old should not take this medication and if need be and there are no other alternatives it should be administered with drops and not with coffee spoon (2.5 ml) or jam spoon (5 ml).