Qi Hui-min
2006
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0
Influential Citations
1
Citations
Quality indicators
Journal
Journal of Reproductive Medicine
Abstract
Objective: To evaluate the effects of antiprogestin mifepristone and lilopristone on the endocrine function of chorionic and decidual cells in vitro.Methods: Decidual and chorionic tissue cultures were treated with different concentrations of mifepristone or lilopristone for 48 h,and the levels of hCG,progesterone(P) and estradiol(E_2) in the culture(medium) were determined by radioimmunoassay.Results: Mifepristone or lilopristone at various concentrations used significantly decreased the levels of hCG,P and E_2(P0.01 to P0.05) and increased the levels of PGF_(2α)(P0.01) in the chorionic and(decidual) tissue cultures.The levels of hCG,P and E_2 in the chorionic and decidual tissue cultures treated with lilopristone were lower than those treated with mifepristone(P0.01 to P0.05) while PGF_(2α) levels were higher than those treated with mifepristone(P0.01 to P0.05).There were negative correlations between the levels of hCG,P,E_2 and the concentration of mifepristone and lilopristone (P0.01 to P0.05).Conclusions: The results indicate that mifepristone and lilopristone inhibit the endocrine function of chorionic and decidual tissue significantly and stimulate the synthesis of prostaglandin in a dose-dependent manner,and the effect of lilopristone is greater than that of mifepristone.