T. Ji
2015
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Quality indicators
Journal
China Medical Engineering
Abstract
【Objective】To study the effect of nalmefene on the earlier postoperative cognitive in patients undergoing Highly selective surgical resection of epileptic foci.【Methods】Fifty epilepsy patients undergoing Highly selective surgical resection of epileptic foci were randomly divided into nalmefene hydrochloride treatment group(n=25) and control group(n=25).The patients in control group received conventional treatment,while those in nalmefene hydrochloride treatment group were administrated with nalmefene hydrochloride 8 μg/(kg·d) by intravenous infusion for 6 days in addition to the conventional treatment.Plasma cortisol and glucose concentration of patients were detected on day 0(d0),day 2(d2),day 4(d4),day 6(d6). The cognitive function of patients in both groups were tested by mini-mental state examination(MMSE)and the incidence rate of cognitive dysfunction were measured after surgery.【Results】1.There were no significant differences(p 0.05) between the both groups in age, gender, ASA degree, and BMI. 2. The cortisol and glucose concentration decreased significantly after the surgery in group N compared to group C. 3. MMSE scores were significantly higher and the incident rates of POCD were lower in group N than those in group C at 7 days after surgery( P0.05). 【Conclusion】Nalmefene used in Highly selective surgical resection of epileptic foci could reduce the incidence of postoperative cognitive dysfunction whose mechanism could be reducing stress response.