A. Python, Y. Charnay, Richard Mikolajewski
Oct 1, 1997
Citations
1
Influential Citations
11
Citations
Quality indicators
Journal
Pharmacology Biochemistry and Behavior
Abstract
Nisoxetine has been shown to block specifically noradrenaline (NA) reuptake. Therefore, this potential antidepressant is a valuable tool for investigating the involvement of the NA system in sleep regulation. This study aimed to investigate the effects of different doses of nisoxetine on sleep parameters in rats. The main effects were observed with the highest dose and concern paradoxical sleep (PS). Indeed, although total sleep time was not modified, PS appeared later and its amount and the number of its episodes were reduced. These changes suggest a critical involvement of NA in the induction of PS.