Tamotsu Kuniyoshi, Y. Kakihana, S. Isowaki
2005
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0
Influential Citations
8
Citations
Quality indicators
Journal
Journal of Anesthesia
Abstract
PurposeThis study was performed in order to assess the effects of olprinone, a phosphodiesterase III inhibitor, on hepatic oxygen delivery (DO2H), oxygen consumption (VO2H), and mitochondrial oxidation in the liver of a porcine endotoxemia model.MethodsFourteen pigs received continuous infusion of endotoxin via the portal vein for 240 min. From t = 150 to t = 240 min, animals were randomly divided into two groups to receive saline (control [CONT]; n = 7), or olprinone (OLP; n = 7) via the central vein.ResultsIn the OLP group, prior to olprinone treatment at 150 min, endotoxin induced significant decreases in the cardiac index (CI; from 120 ± 31 to 65 ± 13 ml·kg−1·min−1; P < 0.01) and DO2H (from 3.58 ± 0.81 to 1.55 ± 0.49 ml·kg−1·min−1; P < 0.01), while VO2H was maintained. After administration of olprinone (from t = 150 to t = 240 min), CI was unchanged, while DO2H increased from 1.55 ± 0.49 to 1.93 ± 0.38 ml·kg−1·min−1 (P < 0.01) and VO2H increased from 0.42 ± 0.28 to 0.69 ± 0.38 ml·kg−1·min−1 (P < 0.01). At t = 240 min, the oxidation level of cytochrome aa3 was significantly higher in the OLP group than in the CONT group (OLP, 66.2 ± 19.3% vs CONT, 26.4 ± 17.3%; P < 0.01).ConclusionOur data for this porcine endotoxemia model suggest that olprinone may have beneficial therapeutic effects in restoring not only systemic and hepatic circulation but also mitochondrial oxidation in the liver.