Zhao Hua-dong
2008
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Journal
Journal of Modern Oncology
Abstract
Objective:To study the suppressive role of aloeemodin on the growth and its effect on the proliferation cycle and apoptosis of human stomach cancer cell line HGC-27.Methods: The survival rate and the inhibitory rate of HGC-27 cell in vitro were detected by MTT colorimetrie assay and cell growth curve assay at different time points under different concentration of aloeemodin;the cell proliferation cycle and the apoptotic rate were examined with flow cytometry analysis.Results: Aloeemodin inhibited the proliferation of HGC-27 cell at G0/G1 phase,decreased the cell ratio at S phase.It suppressed the growth of tumor cells and raised the apoptotic rate in a concentration and time depending manner in a certain extent.Conclusion: Aloeemodin could suppress the proliferation of HGC-27 cell to induce apoptosis and block cell cycle.