Xiaoying Zhang, P. Xu, Hui-Min Zhang
2013
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Abstract
Objective: Racanisodamine hydrochloride is a muscarinic receptor antagonist used surgically as an anaesthetic drug (acesodyne) or vasodilator. This study was designed to investigate whether racanisodamine hydrochloride has a suppressive effect on allergic responses. RBL-2H3 cells activated by the IgE-antigen complex were used to assess whether racanisodamine hydrochloride could stabilize the cellular membrane. Methods: RBL-2H3 cells were sensitized with monoclonal anti-dinitrophenol (DNP) specific IgE and challenged with the antigen DNP-bovine serum albumin (DNP-BSA) in the presence or absence of racanisodamine hydrochloride. Results: It was observed that racanisodamine hydrochloride significantly inhibited β-hexosaminidase release and IL-4 production in IgE-antigen complex-stimulated RBL-2H3 cells and that this anti-allergic activity was concentration-dependent. The maximum inhibition rates for β-hexosaminidase release and IL-4 production were higher than for 1mM dexamethasone. Conclusions: Racanisodamine hydrochloride could suppress IgE-mediated degranulation and may be useful in the prevention and treatment of allergic diseases.