W. Bollag
Nov 1, 1974
Citations
0
Influential Citations
214
Citations
Quality indicators
Journal
European journal of cancer
Abstract
Abstract Retinoic acid has been shown to exert a prophylactic and a therapeutic effect on chemically induced premalignant and malignant epithelial lesions. The development of hypervitaminosis A is the dose limiting factor in its experimental and clinical use. The biological properties of the aromatic retinoic acid analog: ethyl all-trans- 9 -( 4 -methoxy- 2,3,6 -trimethylphenyl)- 3,7 -dimethyl- 2,4,6,8 -nonateraenoate(=I) were examined. The systemic administration of this compound leads to a marked regression of carcinogen iduced established skin papillomas and carcinomas of mice. A method is described for screening of the dissociation between papilloma regression and hypervitaminosis A production. I possesses a therapeutic ratio which is ten times more favorable than that of retinoic acid. The investigation has proven that the antipapilloma effect is not strictly linked with hypervitaminosis A. This raises hopes for finding compounds with an even better therapeutic ratio, useful in the experimental and clinical prophylaxis and therapy of premalignant and malignant epithelial lesions. The mechanism of action is discussed.