V. Dinnendahl, H. Peters, P. Schönhöfer
Sep 15, 1973
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Influential Citations
23
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Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract Sodium salicylate and to a lesser extent acetylsalicylic acid both inhibit the activity of cyclic 3′,5′-AMP-dependent protein kinase measured by the phosphorylation of histone. The competitive type of inhibition is only seen in the presence of cyclic 3′,5′-AMP. In the absence of cyclic 3′,5′-AMP the unstimulated activity of protein kinase is increased. The impairment of function of protein kinase correlates with the previously reported inhibition of binding of cyclic 3′,5′-AMP to cyclic 3′, 5′-AMP-dependent protein kinase and indicates that the action of sodium salicylate may involve the “regulatory site” of the protein kinase.