Feng Qiao-qia
2015
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Journal of Pharmaceutical Research
Abstract
Objective To investigate the protective effect of dexrabeprazole sodium on reflux esophagitis model of rats.Methods Reflux esophagitis induced by pylorus ligation was treated with dexrabeprazole sodium for injection by intravenous injection for one time. The esophagitis index and suppression rate,volume of gastric juice and activity of pepsin were determined. Results The esophagitis index,volume of gastric juice and activity of pepsin in rats pretreated with dexrabeprazole sodium( 4,2,1 mg · kg- 1,iv) were significantly lower than those of the control group. Conclusion Dexrabeprazole sodium had a remarkable protective on reflux esophagitis model of rats.