P. Holma
Feb 1, 1977
Citations
1
Influential Citations
55
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Quality indicators
Journal
Contraception
Abstract
The effect of the oral administration of metandienone (15 mg/day), an anabolic steroid, on spermatogenesis was studied in 15 male athletes. The sperm density per ml decreased 46% after 1 month of use and 73% after 2 months: the latter value being highly pathologic. 3 subjects became azoospermic, 1 of whom had only 1 million sperms/ml. The percentage of motile sperms decreased to about 30% after 2 months of use. The percentage of normally configured sperms decreased from 73 to 65% after 1 month and to 42% after 2 months. There was about a 100% increase in the percentage of sperms with amorphous heads after 2 months of use. There were also marked increases in the frequency of other sperm abnormalities. After 2 months of use, semen acid phosphatase activity was markedly reduced, while semen fructose concentrations were markedly changed after 1 month. The observed changes were reversed after discontinuation of use.