G. Black, R. Clarke, P. Howard
Apr 1, 1969
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Journal
British journal of anaesthesia
Abstract
SUMMARY Teflurane, a halogenated hydrocarbon anaesthetic, was compared with approximately equipotent concentrations of cyclopropane and halothane in studies made in cats. It induced spontaneous ventricular arrhythmias in a higher proportion of animals than halothane, these irregularities being abolished by the intravenous injection of propranolol. Teflurane caused a profound lowering of arterial blood pressure in all the animals studied. As with halothane there was no significant increase in plasma catecholamine level when teflurane was inhaled. Respiratory and metabolic acidosis contributed to a lowering of plasma pH during teflurane anaesthesia. The inhalation of cycloporpane was accompanied by similar changes, whereas halothane caused some respiratory but only slight metabolic acidosis when high concentrations were given to the spontaneously breathing cat.