Y. Yamaoka, K. Ohguchi, T. Itoh
Jun 23, 2009
Citations
1
Influential Citations
16
Citations
Quality indicators
Journal
Bioscience, Biotechnology, and Biochemistry
Abstract
In this study, we examined the effects of theaflavins, polyphenols in black tea, on α melanocyte-stimulating hormone (αMSH)-induced melanogenesis in mouse B16 melanoma cells. Among theaflavins, theaflavin-3,3′-digallate (TF-3) exhibited a potent inhibitory effect on melanogenesis. Our results indicate that the inhibitory effect of TF-3 on melanogenesis is due to suppression of tyrosinase protein and mRNA levels.