H. Yamadera, Shuichi Nakamura, Hideaki Suzuki
Jul 1, 1998
Citations
2
Influential Citations
49
Citations
Quality indicators
Journal
Psychiatry and Clinical Neurosciences
Abstract
Polysomnography was performed on eight healthy men with trazodone hydrochloride, imipramine and placebo. Trazodone hydrochloride increased slow wave sleep significantly. Imipramine prolonged rapid eye movement (REM) latency and decreased the percentage of REM sleep significantly. Trazodone decreased stages 1 and 2 sleep, while imipramine increased it. These findings suggest that the antidepressive effect of trazodone might be different from that of imipramine with the suppression of REM sleep.