H. Z. Giffin, H. Conner
May 4, 1929
Citations
0
Influential Citations
19
Citations
Journal
JAMA
Abstract
Phenylhydrazine hydrochloride has come into general use as a therapeutic agent in the treatment of polycythemia vera. It was employed experimentally in animals in 1885 by Hoppe-Seyler. 1 Morawitz and Pratt 2 in 1908 used it for the purpose of producing experimental anemia in animals, and Eppinger and Kloss 3 in 1918 were the first to apply it clinically in cases of polycythemia vera. The reports that have appeared in the literature since that time concerning the treatment of polycythemia vera by means of phenylhydrazine have, in the main, been very favorable. Good results have been reported by Eppinger and Kloss,3 Taschenberg, 4 Levi, 5 Owen, 6 Brown and Giffin, 7 Altnow and Carey, 8 Stealy 9 and Cabot. 10 Bryan 11 alone called attention to possible serious unfavorable effects of phenylhydrazine. In the early cases an unnecessarily severe anemia was produced and the occurrence of thrombosis was noted. The